Scientific name: Biotinoyl Tripeptide-1
Classification: Peptide
Stimulant, anti-aging, strengthening.
Tales from Nature
Chemically speaking, it is a chimeric molecule obtained from the conjugation of two distinct elements:
Biotin (Vitamin H/B7): Known for its role in amino acid metabolism and carboxylation;
GHK (Glycyl-Histidyl-Lysine)
:
A signal peptide (tripeptide) with high biological affinity, known for its ability to modulate tissue remodeling.
This conjugation creates a synergistic active that exceeds the simple sum of the parts, acting as a follicular unit-specific biological modulator.
Hair Benefits
Scientific benefits in the treatment of hormonal disorders:
In hair subject to hormonal imbalances, the main issues are follicle miniaturization, shortening of the anagen phase, and weakening of the dermo-epidermal junction. Biotinoyl Tripeptide-1 acts on these targets by precise mechanisms:
1. Enhancement of follicular anchorage.
One of the most deleterious effects of hormonal imbalances (particularly the action of DHT) is the weakening of the connective tissue surrounding the bulb, leading to premature hair loss.
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Mechanism of action: Biotinoyl Tripeptide-1 selectively stimulates the synthesis of Laminin-5 and Collagen IV. These proteins are key structural components of the basement membrane and dermal papilla.
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Result: By increasing the density of these adhesion molecules, a firmer mechanical "anchorage" of the hair in the scalp is achieved, reducing the traction required to cause its detachment (reduction of mechanical shedding).
2. Stimulation of mitochondrial metabolism and anagen phase.
The follicle under hormonal stress tends to enter the Telogen (rest/fall) phase early and produce a thin shaft.
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Mechanism of Action: The peptide component acts as a signal to reactivate the metabolism of hair bulb keratinocytes, increasing ATP production and protein synthesis.
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Result: The active helps prolong theanagen phase (active growth phase). This counteracts miniaturization, promoting the production of a larger (thicker) and stronger hair shaft.
3. Anti-aging action of the follicle.
Hormonal surges accelerate cellular aging of the hair follicle.
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Mechanism of action: Biotinoyl Tripeptide-1 reduces the production of pro-inflammatory cytokines (often elevated in androgenetic alopecia) and protects follicle structures from oxidative stress by improving local blood supply.
While Biotin nourishes, Biotinoyl Tripeptide-1 is a cellular architect: it not only provides "building blocks," but sends specific signals to the follicle to "order" the construction of stronger roots and structurally younger hair, actively counteracting hormone-induced weakness.
